Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144149..144654 Replicon chromosome
Accession NZ_CP124664
Organism Pseudomonas aeruginosa strain 2021CK-01256

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag QJ960_RS00650 Protein ID WP_003083773.1
Coordinates 144149..144430 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag QJ960_RS00655 Protein ID WP_003083775.1
Coordinates 144427..144654 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ960_RS00625 (QJ960_00625) 139400..140749 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
QJ960_RS00630 (QJ960_00630) 140798..141484 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QJ960_RS00635 (QJ960_00635) 141585..142319 + 735 WP_003117208.1 GntR family transcriptional regulator -
QJ960_RS00640 (QJ960_00640) 142499..142909 + 411 WP_003101225.1 aegerolysin family protein -
QJ960_RS00645 (QJ960_00645) 142941..143849 - 909 WP_003083769.1 LysR family transcriptional regulator -
QJ960_RS00650 (QJ960_00650) 144149..144430 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
QJ960_RS00655 (QJ960_00655) 144427..144654 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
QJ960_RS00660 (QJ960_00660) 144830..145450 - 621 WP_003101226.1 hypothetical protein -
QJ960_RS00665 (QJ960_00665) 145551..146051 + 501 WP_003101228.1 LEA type 2 family protein -
QJ960_RS00670 (QJ960_00670) 146124..146465 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QJ960_RS00675 (QJ960_00675) 146547..147974 - 1428 WP_031630494.1 GABA permease -
QJ960_RS00680 (QJ960_00680) 148143..149636 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T281018 WP_003083773.1 NZ_CP124664:c144430-144149 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT281018 WP_003083775.1 NZ_CP124664:c144654-144427 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References