281016

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4545174..4546432 Replicon chromosome
Accession NZ_CP124663
Organism Pseudomonas aeruginosa strain 2021CK-01227

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag QJ982_RS21095 Protein ID WP_003086331.1
Coordinates 4545174..4545929 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QJ982_RS21100 Protein ID WP_003086329.1
Coordinates 4546064..4546432 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ982_RS21085 (QJ982_21085) 4540345..4542888 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
QJ982_RS21090 (QJ982_21090) 4543043..4544404 - 1362 WP_073647918.1 DNA recombination protein RmuC -
QJ982_RS21095 (QJ982_21095) 4545174..4545929 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
QJ982_RS21100 (QJ982_21100) 4546064..4546432 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QJ982_RS21105 (QJ982_21105) 4546502..4547788 - 1287 WP_033994983.1 FAD-binding oxidoreductase -
QJ982_RS21110 (QJ982_21110) 4547844..4549337 - 1494 WP_033994982.1 aldehyde dehydrogenase family protein -
QJ982_RS21115 (QJ982_21115) 4549511..4549987 + 477 WP_033994996.1 elongation factor GreAB -
QJ982_RS21120 (QJ982_21120) 4549990..4550265 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T281016 WP_003086331.1 NZ_CP124663:c4545929-4545174 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281016 WP_003086329.1 NZ_CP124663:c4546432-4546064 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References