281015

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3580875..3582095 Replicon chromosome
Accession NZ_CP124663
Organism Pseudomonas aeruginosa strain 2021CK-01227

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag QJ982_RS16575 Protein ID WP_003110488.1
Coordinates 3581517..3582095 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QJ982_RS16570 Protein ID WP_003132728.1
Coordinates 3580875..3581429 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ982_RS16545 (QJ982_16545) 3576443..3576994 + 552 WP_031685890.1 XRE family transcriptional regulator -
QJ982_RS16550 (QJ982_16550) 3576991..3577389 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
QJ982_RS16555 (QJ982_16555) 3577402..3577725 - 324 WP_003102734.1 multidrug efflux SMR transporter -
QJ982_RS16560 (QJ982_16560) 3578056..3578517 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
QJ982_RS16565 (QJ982_16565) 3578522..3580717 + 2196 WP_033957494.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
QJ982_RS16570 (QJ982_16570) 3580875..3581429 + 555 WP_003132728.1 helix-turn-helix transcriptional regulator Antitoxin
QJ982_RS16575 (QJ982_16575) 3581517..3582095 + 579 WP_003110488.1 HD domain-containing protein Toxin
QJ982_RS16580 (QJ982_16580) 3582205..3583392 - 1188 WP_003110489.1 HlyD family efflux transporter periplasmic adaptor subunit -
QJ982_RS16585 (QJ982_16585) 3583382..3585553 - 2172 WP_033957491.1 type I secretion system permease/ATPase -
QJ982_RS16590 (QJ982_16590) 3585543..3586820 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T281015 WP_003110488.1 NZ_CP124663:3581517-3582095 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20470.63 Da        Isoelectric Point: 8.1590

>AT281015 WP_003132728.1 NZ_CP124663:3580875-3581429 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References