Detailed information of TA system TA281014

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1911614..1913122
• Replicon: chromosome
• Accession: NZ_CP124663
• Organism: Pseudomonas aeruginosa strain 2021CK-01227

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: QJ982_RS09005
• Protein ID: WP_023443480.1
• Coordinates: 1911614..1912201 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: QJ982_RS09010
• Protein ID: WP_031685565.1
• Coordinates: 1912268..1913122 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJ982_RS09000 (QJ982_09000)	1907869..1911348	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
QJ982_RS09005 (QJ982_09005)	1911614..1912201	+	588	WP_023443480.1	GNAT family protein	Toxin
QJ982_RS09010 (QJ982_09010)	1912268..1913122	+	855	WP_031685565.1	AraC family transcriptional regulator	Antitoxin
QJ982_RS09015 (QJ982_09015)	1913219..1915384	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
QJ982_RS09020 (QJ982_09020)	1915559..1917433	+	1875	WP_003091605.1	MFS transporter	-
QJ982_RS09025 (QJ982_09025)	1917494..1917703	-	210	WP_003091604.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21931.26 Da
• Isoelectric Point: 9.8676

>T281014 WP_023443480.1 NZ_CP124663:1911614-1912201 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRTLPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31819.13 Da
• Isoelectric Point: 7.8141

>AT281014 WP_031685565.1 NZ_CP124663:1912268-1913122 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLAPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Nucleotide

• Length: 855 bp