281013

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1642433..1644128 Replicon chromosome
Accession NZ_CP124663
Organism Pseudomonas aeruginosa strain 2021CK-01227

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag QJ982_RS07745 Protein ID WP_003112901.1
Coordinates 1642433..1643302 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag QJ982_RS07750 Protein ID WP_003112902.1
Coordinates 1643295..1644128 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ982_RS07720 (QJ982_07720) 1638441..1639292 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
QJ982_RS07725 (QJ982_07725) 1639333..1640340 + 1008 WP_023097315.1 ABC transporter substrate-binding protein -
QJ982_RS07730 (QJ982_07730) 1640337..1641113 + 777 WP_003112898.1 ABC transporter permease -
QJ982_RS07735 (QJ982_07735) 1641119..1641880 + 762 WP_003112899.1 SDR family oxidoreductase -
QJ982_RS07740 (QJ982_07740) 1641894..1642424 + 531 WP_031685488.1 cupin domain-containing protein -
QJ982_RS07745 (QJ982_07745) 1642433..1643302 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
QJ982_RS07750 (QJ982_07750) 1643295..1644128 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
QJ982_RS07755 (QJ982_07755) 1644115..1644912 + 798 WP_023111480.1 SDR family oxidoreductase -
QJ982_RS07760 (QJ982_07760) 1644905..1646587 + 1683 WP_031685491.1 thiamine pyrophosphate-binding protein -
QJ982_RS07765 (QJ982_07765) 1646598..1647401 + 804 WP_003130116.1 aspartate dehydrogenase -
QJ982_RS07770 (QJ982_07770) 1647413..1648897 + 1485 WP_031685492.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T281013 WP_003112901.1 NZ_CP124663:1642433-1643302 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT281013 WP_003112902.1 NZ_CP124663:1643295-1644128 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References