281012

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142848..143353 Replicon chromosome
Accession NZ_CP124663
Organism Pseudomonas aeruginosa strain 2021CK-01227

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag QJ982_RS00655 Protein ID WP_003083773.1
Coordinates 142848..143129 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag QJ982_RS00660 Protein ID WP_003083775.1
Coordinates 143126..143353 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ982_RS00630 (QJ982_00630) 138098..139447 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
QJ982_RS00635 (QJ982_00635) 139496..140182 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QJ982_RS00640 (QJ982_00640) 140283..141017 + 735 WP_003110658.1 GntR family transcriptional regulator -
QJ982_RS00645 (QJ982_00645) 141197..141607 + 411 WP_003110659.1 aegerolysin family protein -
QJ982_RS00650 (QJ982_00650) 141639..142547 - 909 WP_003083769.1 LysR family transcriptional regulator -
QJ982_RS00655 (QJ982_00655) 142848..143129 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
QJ982_RS00660 (QJ982_00660) 143126..143353 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
QJ982_RS00665 (QJ982_00665) 143529..144149 - 621 WP_003101226.1 hypothetical protein -
QJ982_RS00670 (QJ982_00670) 144250..144750 + 501 WP_003101228.1 LEA type 2 family protein -
QJ982_RS00675 (QJ982_00675) 144823..145164 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QJ982_RS00680 (QJ982_00680) 145246..146673 - 1428 WP_003083784.1 GABA permease -
QJ982_RS00685 (QJ982_00685) 146842..148335 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T281012 WP_003083773.1 NZ_CP124663:c143129-142848 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT281012 WP_003083775.1 NZ_CP124663:c143353-143126 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References