281010

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5843407..5843993 Replicon chromosome
Accession NZ_CP124662
Organism Pseudomonas aeruginosa strain 2021CK-01633

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I91_RS27690 Protein ID WP_003120987.1
Coordinates 5843694..5843993 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I91_RS27685 Protein ID WP_003448662.1
Coordinates 5843407..5843697 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I91_RS27670 (P7I91_27670) 5838982..5840877 + 1896 WP_155713823.1 hypothetical protein -
P7I91_RS27675 (P7I91_27675) 5840874..5842850 + 1977 WP_023093671.1 DEAD/DEAH box helicase -
P7I91_RS27680 (P7I91_27680) 5842989..5843324 + 336 WP_022579623.1 hypothetical protein -
P7I91_RS27685 (P7I91_27685) 5843407..5843697 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I91_RS27690 (P7I91_27690) 5843694..5843993 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I91_RS27695 (P7I91_27695) 5844195..5845319 + 1125 WP_023093672.1 TcpQ domain-containing protein -
P7I91_RS27700 (P7I91_27700) 5845319..5847028 + 1710 WP_023093673.1 PilN family type IVB pilus formation outer membrane protein -
P7I91_RS27705 (P7I91_27705) 5847032..5848357 + 1326 WP_022579625.1 type 4b pilus protein PilO2 -
P7I91_RS27710 (P7I91_27710) 5848347..5848880 + 534 WP_003149521.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5812908..5901081 88173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T281010 WP_003120987.1 NZ_CP124662:c5843993-5843694 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT281010 WP_003448662.1 NZ_CP124662:c5843697-5843407 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References