281009

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5054804..5055390 Replicon chromosome
Accession NZ_CP124662
Organism Pseudomonas aeruginosa strain 2021CK-01633

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I91_RS23685 Protein ID WP_003120987.1
Coordinates 5055091..5055390 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I91_RS23680 Protein ID WP_003448662.1
Coordinates 5054804..5055094 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I91_RS23660 (P7I91_23660) 5050386..5052275 + 1890 WP_003448700.1 hypothetical protein -
P7I91_RS23665 (P7I91_23665) 5052272..5054248 + 1977 WP_010792226.1 DEAD/DEAH box helicase -
P7I91_RS23670 (P7I91_23670) 5054258..5054392 + 135 WP_033179080.1 hypothetical protein -
P7I91_RS23675 (P7I91_23675) 5054389..5054733 + 345 WP_003448665.1 hypothetical protein -
P7I91_RS23680 (P7I91_23680) 5054804..5055094 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I91_RS23685 (P7I91_23685) 5055091..5055390 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I91_RS23690 (P7I91_23690) 5055592..5056713 + 1122 WP_003448658.1 TcpQ domain-containing protein -
P7I91_RS23695 (P7I91_23695) 5056713..5058422 + 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
P7I91_RS23700 (P7I91_23700) 5058426..5059751 + 1326 WP_003120992.1 type 4b pilus protein PilO2 -
P7I91_RS23705 (P7I91_23705) 5059741..5060274 + 534 WP_003120993.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5026641..5108186 81545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T281009 WP_003120987.1 NZ_CP124662:c5055390-5055091 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT281009 WP_003448662.1 NZ_CP124662:c5055094-5054804 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References