281008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4957400..4958658 Replicon chromosome
Accession NZ_CP124662
Organism Pseudomonas aeruginosa strain 2021CK-01633

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I91_RS23175 Protein ID WP_003086331.1
Coordinates 4957400..4958155 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I91_RS23180 Protein ID WP_003086329.1
Coordinates 4958290..4958658 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I91_RS23165 (P7I91_23165) 4952571..4955114 + 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -
P7I91_RS23170 (P7I91_23170) 4955269..4956630 - 1362 WP_003081943.1 DNA recombination protein RmuC -
P7I91_RS23175 (P7I91_23175) 4957400..4958155 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I91_RS23180 (P7I91_23180) 4958290..4958658 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I91_RS23185 (P7I91_23185) 4958731..4960017 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I91_RS23190 (P7I91_23190) 4960073..4961566 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P7I91_RS23195 (P7I91_23195) 4961741..4962217 + 477 WP_004353334.1 elongation factor GreAB -
P7I91_RS23200 (P7I91_23200) 4962220..4962480 - 261 WP_023095977.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T281008 WP_003086331.1 NZ_CP124662:c4958155-4957400 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281008 WP_003086329.1 NZ_CP124662:c4958658-4958290 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References