281007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3971272..3972492 Replicon chromosome
Accession NZ_CP124662
Organism Pseudomonas aeruginosa strain 2021CK-01633

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I91_RS18470 Protein ID WP_003110488.1
Coordinates 3971914..3972492 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I91_RS18465 Protein ID WP_003088112.1
Coordinates 3971272..3971826 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I91_RS18440 (P7I91_18440) 3966840..3967391 + 552 WP_003132721.1 XRE family transcriptional regulator -
P7I91_RS18445 (P7I91_18445) 3967388..3967786 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I91_RS18450 (P7I91_18450) 3967799..3968122 - 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I91_RS18455 (P7I91_18455) 3968453..3968914 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
P7I91_RS18460 (P7I91_18460) 3968919..3971114 + 2196 WP_023095788.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I91_RS18465 (P7I91_18465) 3971272..3971826 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P7I91_RS18470 (P7I91_18470) 3971914..3972492 + 579 WP_003110488.1 HD domain-containing protein Toxin
P7I91_RS18475 (P7I91_18475) 3972602..3973789 - 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I91_RS18480 (P7I91_18480) 3973779..3975950 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
P7I91_RS18485 (P7I91_18485) 3975940..3977217 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T281007 WP_003110488.1 NZ_CP124662:3971914-3972492 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT281007 WP_003088112.1 NZ_CP124662:3971272-3971826 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References