Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2620097..2620650 Replicon chromosome
Accession NZ_CP124662
Organism Pseudomonas aeruginosa strain 2021CK-01633

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag P7I91_RS12355 Protein ID WP_010953434.1
Coordinates 2620357..2620650 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A431XAN4
Locus tag P7I91_RS12350 Protein ID WP_003155922.1
Coordinates 2620097..2620369 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I91_RS12345 (P7I91_12345) 2619728..2619973 + 246 WP_034065762.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
P7I91_RS12350 (P7I91_12350) 2620097..2620369 + 273 WP_003155922.1 CopG family ribbon-helix-helix protein Antitoxin
P7I91_RS12355 (P7I91_12355) 2620357..2620650 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I91_RS12360 (P7I91_12360) 2620644..2622053 - 1410 WP_034065764.1 site-specific integrase -
P7I91_RS12365 (P7I91_12365) 2622470..2623171 - 702 WP_031640384.1 hypothetical protein -
P7I91_RS12370 (P7I91_12370) 2623287..2623433 + 147 Protein_2443 DNA binding protein -
P7I91_RS12375 (P7I91_12375) 2623561..2625351 - 1791 WP_023095445.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2585771..2629476 43705
- inside Genomic island - - 2584851..2629476 44625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T281006 WP_010953434.1 NZ_CP124662:2620357-2620650 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10369.53 Da        Isoelectric Point: 6.0804

>AT281006 WP_003155922.1 NZ_CP124662:2620097-2620369 [Pseudomonas aeruginosa]
MATSIKIDDELKGRIQHLAGLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB A0A431XAN4

References