Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5039301..5040559 Replicon chromosome
Accession NZ_CP124660
Organism Pseudomonas aeruginosa strain 2022CK-00160

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag P7I96_RS23890 Protein ID WP_003449003.1
Coordinates 5039301..5040056 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I96_RS23895 Protein ID WP_003086329.1
Coordinates 5040191..5040559 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I96_RS23880 (P7I96_23880) 5034474..5037017 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
P7I96_RS23885 (P7I96_23885) 5037172..5038533 - 1362 WP_073647918.1 DNA recombination protein RmuC -
P7I96_RS23890 (P7I96_23890) 5039301..5040056 - 756 WP_003449003.1 RES family NAD+ phosphorylase Toxin
P7I96_RS23895 (P7I96_23895) 5040191..5040559 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I96_RS23900 (P7I96_23900) 5040632..5041918 - 1287 WP_003449000.1 FAD-binding oxidoreductase -
P7I96_RS23905 (P7I96_23905) 5041974..5043467 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P7I96_RS23910 (P7I96_23910) 5043642..5044118 + 477 WP_003112531.1 hypothetical protein -
P7I96_RS23915 (P7I96_23915) 5044121..5044396 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28292.45 Da        Isoelectric Point: 7.7294

>T281001 WP_003449003.1 NZ_CP124660:c5040056-5039301 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281001 WP_003086329.1 NZ_CP124660:c5040559-5040191 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References