Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 4010797..4012018 | Replicon | chromosome |
| Accession | NZ_CP124660 | ||
| Organism | Pseudomonas aeruginosa strain 2022CK-00160 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | P7I96_RS18945 | Protein ID | WP_003160088.1 |
| Coordinates | 4011440..4012018 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | P7I96_RS18940 | Protein ID | WP_003088112.1 |
| Coordinates | 4010797..4011351 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P7I96_RS18915 (P7I96_18915) | 4006365..4006916 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
| P7I96_RS18920 (P7I96_18920) | 4006913..4007311 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| P7I96_RS18925 (P7I96_18925) | 4007324..4007647 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| P7I96_RS18930 (P7I96_18930) | 4007978..4008439 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| P7I96_RS18935 (P7I96_18935) | 4008444..4010639 | + | 2196 | WP_034010345.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| P7I96_RS18940 (P7I96_18940) | 4010797..4011351 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| P7I96_RS18945 (P7I96_18945) | 4011440..4012018 | + | 579 | WP_003160088.1 | HD domain-containing protein | Toxin |
| P7I96_RS18950 (P7I96_18950) | 4012127..4013314 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| P7I96_RS18955 (P7I96_18955) | 4013304..4015475 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| P7I96_RS18960 (P7I96_18960) | 4015465..4016742 | - | 1278 | WP_003160086.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21816.65 Da Isoelectric Point: 5.1625
>T281000 WP_003160088.1 NZ_CP124660:4011440-4012018 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT281000 WP_003088112.1 NZ_CP124660:4010797-4011351 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|