Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2868164..2868873 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag RVBD_RS13475 Protein ID WP_003413164.1
Coordinates 2868164..2868577 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag RVBD_RS13480 Protein ID WP_003413167.1
Coordinates 2868616..2868873 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS13445 2863217..2864422 - 1206 WP_003413027.1 chorismate synthase -
RVBD_RS13450 2864530..2864844 + 315 WP_009937839.1 hypothetical protein -
RVBD_RS13455 2865140..2866351 + 1212 WP_009936235.1 alpha/beta hydrolase family protein -
RVBD_RS13460 2866478..2867137 + 660 WP_003900846.1 LppA family lipoprotein -
RVBD_RS13465 2867134..2867796 + 663 WP_003900848.1 hypothetical protein -
RVBD_RS13470 2867793..2868071 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
RVBD_RS13475 2868164..2868577 + 414 WP_003413164.1 PIN domain nuclease Toxin
RVBD_RS13480 2868616..2868873 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
RVBD_RS13485 2868870..2869247 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
RVBD_RS13490 2869263..2869637 - 375 WP_003413177.1 hypothetical protein -
RVBD_RS13495 2869737..2870132 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
RVBD_RS13500 2870129..2870374 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
RVBD_RS13505 2870785..2871204 - 420 WP_003413190.1 A24 family peptidase -
RVBD_RS13510 2871216..2872025 - 810 WP_003413193.1 shikimate dehydrogenase -
RVBD_RS13515 2872022..2873275 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
RVBD_RS13520 2873268..2873780 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T28100 WP_003413164.1 NC_018143:2868164-2868577 [Mycobacterium tuberculosis H37Rv]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T28100 NC_018143:2868164-2868577 [Mycobacterium tuberculosis H37Rv]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT28100 WP_003413167.1 NC_018143:2868616-2868873 [Mycobacterium tuberculosis H37Rv]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT28100 NC_018143:2868616-2868873 [Mycobacterium tuberculosis H37Rv]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References