Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2096861..2098369 Replicon chromosome
Accession NZ_CP124660
Organism Pseudomonas aeruginosa strain 2022CK-00160

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag P7I96_RS09950 Protein ID WP_003119682.1
Coordinates 2096861..2097448 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag P7I96_RS09955 Protein ID WP_003119683.1
Coordinates 2097515..2098369 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I96_RS09945 (P7I96_09945) 2093116..2096595 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
P7I96_RS09950 (P7I96_09950) 2096861..2097448 + 588 WP_003119682.1 GNAT family protein Toxin
P7I96_RS09955 (P7I96_09955) 2097515..2098369 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
P7I96_RS09960 (P7I96_09960) 2098466..2100631 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
P7I96_RS09965 (P7I96_09965) 2100806..2102680 + 1875 WP_003091605.1 MFS transporter -
P7I96_RS09970 (P7I96_09970) 2102740..2102949 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T280998 WP_003119682.1 NZ_CP124660:2096861-2097448 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT280998 WP_003119683.1 NZ_CP124660:2097515-2098369 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References