Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143984..144489 Replicon chromosome
Accession NZ_CP124660
Organism Pseudomonas aeruginosa strain 2022CK-00160

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag P7I96_RS00665 Protein ID WP_003121619.1
Coordinates 143984..144265 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag P7I96_RS00670 Protein ID WP_003112628.1
Coordinates 144262..144489 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I96_RS00640 (P7I96_00640) 139235..140584 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
P7I96_RS00645 (P7I96_00645) 140633..141319 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P7I96_RS00650 (P7I96_00650) 141420..142154 + 735 WP_003117208.1 GntR family transcriptional regulator -
P7I96_RS00655 (P7I96_00655) 142334..142744 + 411 WP_003101225.1 aegerolysin family protein -
P7I96_RS00660 (P7I96_00660) 142776..143684 - 909 WP_016561475.1 LysR family transcriptional regulator -
P7I96_RS00665 (P7I96_00665) 143984..144265 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
P7I96_RS00670 (P7I96_00670) 144262..144489 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
P7I96_RS00675 (P7I96_00675) 144665..145285 - 621 WP_003101226.1 hypothetical protein -
P7I96_RS00680 (P7I96_00680) 145386..145886 + 501 WP_003101228.1 LEA type 2 family protein -
P7I96_RS00685 (P7I96_00685) 145959..146300 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
P7I96_RS00690 (P7I96_00690) 146382..147809 - 1428 WP_003083784.1 GABA permease -
P7I96_RS00695 (P7I96_00695) 147978..149471 - 1494 WP_043105480.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T280997 WP_003121619.1 NZ_CP124660:c144265-143984 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT280997 WP_003112628.1 NZ_CP124660:c144489-144262 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References