Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 244068..244984 Replicon plasmid unnamed1
Accession NZ_CP124659
Organism Pseudomonas aeruginosa strain 2022CK-00068

Toxin (Protein)


Gene name slvT Uniprot ID A0A2I0C753
Locus tag P7I93_RS34205 Protein ID WP_058131799.1
Coordinates 244460..244984 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2I0C738
Locus tag P7I93_RS34200 Protein ID WP_010792483.1
Coordinates 244068..244463 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I93_RS34190 (P7I93_34190) 239462..239866 - 405 WP_033997852.1 response regulator -
P7I93_RS34195 (P7I93_34195) 241599..243482 + 1884 WP_235369486.1 helicase -
P7I93_RS34200 (P7I93_34200) 244068..244463 + 396 WP_010792483.1 hypothetical protein Antitoxin
P7I93_RS34205 (P7I93_34205) 244460..244984 + 525 WP_058131799.1 RES family NAD+ phosphorylase Toxin
P7I93_RS34210 (P7I93_34210) 245030..246280 - 1251 WP_210674650.1 TerD family protein -
P7I93_RS34215 (P7I93_34215) 246679..246870 + 192 WP_058131795.1 hypothetical protein -
P7I93_RS34220 (P7I93_34220) 247291..248169 - 879 WP_282499086.1 glycerate kinase -
P7I93_RS34225 (P7I93_34225) 248405..249919 + 1515 WP_212739819.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib / qnrVC1 / dfrA15 / qacE / sul1 / aac(6')-Il / blaVIM-2 / aph(3')-VIa - 1..526642 526642


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19069.61 Da        Isoelectric Point: 4.4540

>T280996 WP_058131799.1 NZ_CP124659:244460-244984 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWMRP

Download         Length: 525 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14810.93 Da        Isoelectric Point: 7.2048

>AT280996 WP_010792483.1 NZ_CP124659:244068-244463 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I0C753

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0C738

References