280995

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 131143..131836 Replicon plasmid unnamed1
Accession NZ_CP124659
Organism Pseudomonas aeruginosa strain 2022CK-00068

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag P7I93_RS33700 Protein ID WP_003151133.1
Coordinates 131459..131836 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag P7I93_RS33695 Protein ID WP_001172026.1
Coordinates 131143..131478 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I93_RS33665 (P7I93_33665) 126863..127363 + 501 WP_000376623.1 GNAT family N-acetyltransferase -
P7I93_RS33670 (P7I93_33670) 127332..128324 - 993 WP_003107582.1 TniB family NTP-binding protein -
P7I93_RS33675 (P7I93_33675) 128327..130006 - 1680 WP_000179844.1 DDE-type integrase/transposase/recombinase -
P7I93_RS33680 (P7I93_33680) 130086..130427 - 342 WP_025999701.1 hypothetical protein -
P7I93_RS33685 (P7I93_33685) 130443..130769 - 327 WP_000091614.1 hypothetical protein -
P7I93_RS33690 (P7I93_33690) 130793..131128 - 336 WP_000741275.1 hypothetical protein -
P7I93_RS33695 (P7I93_33695) 131143..131478 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
P7I93_RS33700 (P7I93_33700) 131459..131836 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I93_RS33705 (P7I93_33705) 132028..132630 + 603 WP_010465829.1 recombinase family protein -
P7I93_RS33710 (P7I93_33710) 132614..135643 + 3030 WP_010799689.1 Tn3 family transposase -
P7I93_RS33715 (P7I93_33715) 135700..136464 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
P7I93_RS33720 (P7I93_33720) 136582..136650 - 69 Protein_160 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib / qnrVC1 / dfrA15 / qacE / sul1 / aac(6')-Il / blaVIM-2 / aph(3')-VIa - 1..526642 526642


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T280995 WP_003151133.1 NZ_CP124659:c131836-131459 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT280995 WP_001172026.1 NZ_CP124659:c131478-131143 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References