Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4841127..4841713 Replicon chromosome
Accession NZ_CP124658
Organism Pseudomonas aeruginosa strain 2022CK-00068

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I93_RS22905 Protein ID WP_003120987.1
Coordinates 4841414..4841713 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I93_RS22900 Protein ID WP_003448662.1
Coordinates 4841127..4841417 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I93_RS22880 (P7I93_22880) 4836278..4836487 + 210 WP_003105733.1 cold-shock protein -
P7I93_RS22885 (P7I93_22885) 4836709..4838598 + 1890 WP_016851610.1 hypothetical protein -
P7I93_RS22890 (P7I93_22890) 4838595..4840571 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
P7I93_RS22895 (P7I93_22895) 4840712..4841056 + 345 WP_016851612.1 hypothetical protein -
P7I93_RS22900 (P7I93_22900) 4841127..4841417 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I93_RS22905 (P7I93_22905) 4841414..4841713 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I93_RS22910 (P7I93_22910) 4841915..4843036 + 1122 WP_021263359.1 TcpQ domain-containing protein -
P7I93_RS22915 (P7I93_22915) 4843036..4844745 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
P7I93_RS22920 (P7I93_22920) 4844749..4846074 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
P7I93_RS22925 (P7I93_22925) 4846064..4846597 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4813281..4841713 28432


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T280993 WP_003120987.1 NZ_CP124658:c4841713-4841414 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT280993 WP_003448662.1 NZ_CP124658:c4841417-4841127 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References