Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4762640..4763898 Replicon chromosome
Accession NZ_CP124658
Organism Pseudomonas aeruginosa strain 2022CK-00068

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I93_RS22475 Protein ID WP_003086331.1
Coordinates 4762640..4763395 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I93_RS22480 Protein ID WP_003086329.1
Coordinates 4763530..4763898 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I93_RS22465 (P7I93_22465) 4757811..4760354 + 2544 WP_009315399.1 acyl-homoserine-lactone acylase QuiP -
P7I93_RS22470 (P7I93_22470) 4760509..4761870 - 1362 WP_003134034.1 DNA recombination protein RmuC -
P7I93_RS22475 (P7I93_22475) 4762640..4763395 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I93_RS22480 (P7I93_22480) 4763530..4763898 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I93_RS22485 (P7I93_22485) 4763971..4765257 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I93_RS22490 (P7I93_22490) 4765313..4766806 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P7I93_RS22495 (P7I93_22495) 4766981..4767457 + 477 WP_003112531.1 hypothetical protein -
P7I93_RS22500 (P7I93_22500) 4767460..4767735 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280992 WP_003086331.1 NZ_CP124658:c4763395-4762640 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280992 WP_003086329.1 NZ_CP124658:c4763898-4763530 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References