Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3742048..3743269 Replicon chromosome
Accession NZ_CP124658
Organism Pseudomonas aeruginosa strain 2022CK-00068

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I93_RS17705 Protein ID WP_003110488.1
Coordinates 3742691..3743269 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I93_RS17700 Protein ID WP_003088112.1
Coordinates 3742048..3742602 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I93_RS17675 (P7I93_17675) 3737616..3738167 + 552 WP_003132721.1 XRE family transcriptional regulator -
P7I93_RS17680 (P7I93_17680) 3738164..3738562 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I93_RS17685 (P7I93_17685) 3738575..3738898 - 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I93_RS17690 (P7I93_17690) 3739229..3739690 + 462 WP_003088117.1 (2Fe-2S)-binding protein -
P7I93_RS17695 (P7I93_17695) 3739695..3741890 + 2196 WP_023091929.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I93_RS17700 (P7I93_17700) 3742048..3742602 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P7I93_RS17705 (P7I93_17705) 3742691..3743269 + 579 WP_003110488.1 HD domain-containing protein Toxin
P7I93_RS17710 (P7I93_17710) 3743379..3744566 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I93_RS17715 (P7I93_17715) 3744556..3746727 - 2172 WP_003110490.1 type I secretion system permease/ATPase -
P7I93_RS17720 (P7I93_17720) 3746717..3747994 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T280991 WP_003110488.1 NZ_CP124658:3742691-3743269 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT280991 WP_003088112.1 NZ_CP124658:3742048-3742602 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References