Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3742048..3743269 | Replicon | chromosome |
Accession | NZ_CP124658 | ||
Organism | Pseudomonas aeruginosa strain 2022CK-00068 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0H2Z8V4 |
Locus tag | P7I93_RS17705 | Protein ID | WP_003110488.1 |
Coordinates | 3742691..3743269 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | P7I93_RS17700 | Protein ID | WP_003088112.1 |
Coordinates | 3742048..3742602 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P7I93_RS17675 (P7I93_17675) | 3737616..3738167 | + | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
P7I93_RS17680 (P7I93_17680) | 3738164..3738562 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
P7I93_RS17685 (P7I93_17685) | 3738575..3738898 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
P7I93_RS17690 (P7I93_17690) | 3739229..3739690 | + | 462 | WP_003088117.1 | (2Fe-2S)-binding protein | - |
P7I93_RS17695 (P7I93_17695) | 3739695..3741890 | + | 2196 | WP_023091929.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
P7I93_RS17700 (P7I93_17700) | 3742048..3742602 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
P7I93_RS17705 (P7I93_17705) | 3742691..3743269 | + | 579 | WP_003110488.1 | HD domain-containing protein | Toxin |
P7I93_RS17710 (P7I93_17710) | 3743379..3744566 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
P7I93_RS17715 (P7I93_17715) | 3744556..3746727 | - | 2172 | WP_003110490.1 | type I secretion system permease/ATPase | - |
P7I93_RS17720 (P7I93_17720) | 3746717..3747994 | - | 1278 | WP_003088104.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.75 Da Isoelectric Point: 5.3655
>T280991 WP_003110488.1 NZ_CP124658:3742691-3743269 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT280991 WP_003088112.1 NZ_CP124658:3742048-3742602 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|