280990

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2391713..2392755 Replicon chromosome
Accession NZ_CP124658
Organism Pseudomonas aeruginosa strain 2022CK-00068

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag P7I93_RS11320 Protein ID WP_003109777.1
Coordinates 2392180..2392755 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag P7I93_RS11315 Protein ID WP_003050245.1
Coordinates 2391713..2392183 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I93_RS11280 (P7I93_11280) 2387105..2388523 - 1419 WP_031691871.1 TIGR03752 family integrating conjugative element protein -
P7I93_RS11285 (P7I93_11285) 2388513..2389424 - 912 WP_003105643.1 TIGR03749 family integrating conjugative element protein -
P7I93_RS11290 (P7I93_11290) 2389421..2390113 - 693 WP_003105641.1 TIGR03746 family integrating conjugative element protein -
P7I93_RS11295 (P7I93_11295) 2390110..2390508 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
P7I93_RS11300 (P7I93_11300) 2390520..2390879 - 360 WP_023980178.1 TIGR03745 family integrating conjugative element membrane protein -
P7I93_RS11305 (P7I93_11305) 2390896..2391129 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
P7I93_RS11310 (P7I93_11310) 2391126..2391509 - 384 WP_003105635.1 RAQPRD family integrative conjugative element protein -
P7I93_RS11315 (P7I93_11315) 2391713..2392183 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
P7I93_RS11320 (P7I93_11320) 2392180..2392755 + 576 WP_003109777.1 PIN domain-containing protein Toxin
P7I93_RS11325 (P7I93_11325) 2392773..2393687 + 915 WP_003105629.1 AAA family ATPase -
P7I93_RS11330 (P7I93_11330) 2393684..2394154 + 471 WP_003105626.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
P7I93_RS11335 (P7I93_11335) 2394151..2394651 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
P7I93_RS11340 (P7I93_11340) 2394651..2395553 + 903 WP_003105624.1 CBASS oligonucleotide cyclase -
P7I93_RS11345 (P7I93_11345) 2395592..2396317 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2341779..2405042 63263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T280990 WP_003109777.1 NZ_CP124658:2392180-2392755 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT280990 WP_003050245.1 NZ_CP124658:2391713-2392183 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References