Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /Acetyltransf_4(toxin) |
Location | 1840448..1841956 | Replicon | chromosome |
Accession | NZ_CP124658 | ||
Organism | Pseudomonas aeruginosa strain 2022CK-00068 |
Toxin (Protein)
Gene name | - | Uniprot ID | Q9HYX1 |
Locus tag | P7I93_RS08600 | Protein ID | WP_003119682.1 |
Coordinates | 1840448..1841035 (+) | Length | 196 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A1C7C4U7 |
Locus tag | P7I93_RS08605 | Protein ID | WP_003091607.1 |
Coordinates | 1841102..1841956 (+) | Length | 285 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P7I93_RS08595 (P7I93_08595) | 1836703..1840182 | - | 3480 | WP_003117605.1 | PAS domain-containing hybrid sensor histidine kinase/response regulator | - |
P7I93_RS08600 (P7I93_08600) | 1840448..1841035 | + | 588 | WP_003119682.1 | GNAT family protein | Toxin |
P7I93_RS08605 (P7I93_08605) | 1841102..1841956 | + | 855 | WP_003091607.1 | AraC family transcriptional regulator | Antitoxin |
P7I93_RS08610 (P7I93_08610) | 1842053..1844218 | + | 2166 | WP_003091606.1 | TonB-dependent receptor family protein | - |
P7I93_RS08615 (P7I93_08615) | 1844393..1846267 | + | 1875 | WP_003091605.1 | MFS transporter | - |
P7I93_RS08620 (P7I93_08620) | 1846328..1846537 | - | 210 | WP_003091604.1 | cold-shock protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 196 a.a. Molecular weight: 21901.23 Da Isoelectric Point: 9.8676
>T280989 WP_003119682.1 NZ_CP124658:1840448-1841035 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
Download Length: 588 bp
Antitoxin
Download Length: 285 a.a. Molecular weight: 31895.20 Da Isoelectric Point: 7.5295
>AT280989 WP_003091607.1 NZ_CP124658:1841102-1841956 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE
Download Length: 855 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 1YRE | |
PDB | 8GXJ |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1C7C4U7 |