Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1840448..1841956 Replicon chromosome
Accession NZ_CP124658
Organism Pseudomonas aeruginosa strain 2022CK-00068

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag P7I93_RS08600 Protein ID WP_003119682.1
Coordinates 1840448..1841035 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag P7I93_RS08605 Protein ID WP_003091607.1
Coordinates 1841102..1841956 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I93_RS08595 (P7I93_08595) 1836703..1840182 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
P7I93_RS08600 (P7I93_08600) 1840448..1841035 + 588 WP_003119682.1 GNAT family protein Toxin
P7I93_RS08605 (P7I93_08605) 1841102..1841956 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
P7I93_RS08610 (P7I93_08610) 1842053..1844218 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
P7I93_RS08615 (P7I93_08615) 1844393..1846267 + 1875 WP_003091605.1 MFS transporter -
P7I93_RS08620 (P7I93_08620) 1846328..1846537 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T280989 WP_003119682.1 NZ_CP124658:1840448-1841035 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT280989 WP_003091607.1 NZ_CP124658:1841102-1841956 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References