Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150698..151203 Replicon chromosome
Accession NZ_CP124658
Organism Pseudomonas aeruginosa strain 2022CK-00068

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag P7I93_RS00685 Protein ID WP_003083773.1
Coordinates 150698..150979 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag P7I93_RS00690 Protein ID WP_003083775.1
Coordinates 150976..151203 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I93_RS00660 (P7I93_00660) 145949..147298 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
P7I93_RS00665 (P7I93_00665) 147347..148033 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P7I93_RS00670 (P7I93_00670) 148134..148868 + 735 WP_003083764.1 GntR family transcriptional regulator -
P7I93_RS00675 (P7I93_00675) 149048..149458 + 411 WP_003110659.1 aegerolysin family protein -
P7I93_RS00680 (P7I93_00680) 149490..150398 - 909 WP_003083769.1 LysR family transcriptional regulator -
P7I93_RS00685 (P7I93_00685) 150698..150979 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
P7I93_RS00690 (P7I93_00690) 150976..151203 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
P7I93_RS00695 (P7I93_00695) 151379..151999 - 621 WP_023092259.1 hypothetical protein -
P7I93_RS00700 (P7I93_00700) 152100..152600 + 501 WP_003101228.1 LEA type 2 family protein -
P7I93_RS00705 (P7I93_00705) 152673..153014 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
P7I93_RS00710 (P7I93_00710) 153096..154523 - 1428 WP_023092260.1 GABA permease -
P7I93_RS00715 (P7I93_00715) 154692..156185 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T280988 WP_003083773.1 NZ_CP124658:c150979-150698 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT280988 WP_003083775.1 NZ_CP124658:c151203-150976 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References