Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 6590813..6591729 | Replicon | chromosome |
| Accession | NZ_CP124657 | ||
| Organism | Pseudomonas aeruginosa strain 2022CK-00069 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A212BIN6 |
| Locus tag | P7I94_RS31545 | Protein ID | WP_021018402.1 |
| Coordinates | 6590813..6591337 (-) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A2I0C738 |
| Locus tag | P7I94_RS31550 | Protein ID | WP_010792483.1 |
| Coordinates | 6591334..6591729 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P7I94_RS31525 (P7I94_31530) | 6586130..6587275 | + | 1146 | WP_021018404.1 | glycerate kinase | - |
| P7I94_RS31530 (P7I94_31535) | 6587697..6587888 | - | 192 | WP_010792486.1 | hypothetical protein | - |
| P7I94_RS31535 (P7I94_31540) | 6588265..6589320 | + | 1056 | WP_282414915.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| P7I94_RS31540 (P7I94_31545) | 6589517..6590767 | + | 1251 | WP_010792484.1 | TerD family protein | - |
| P7I94_RS31545 (P7I94_31550) | 6590813..6591337 | - | 525 | WP_021018402.1 | RES family NAD+ phosphorylase | Toxin |
| P7I94_RS31550 (P7I94_31555) | 6591334..6591729 | - | 396 | WP_010792483.1 | hypothetical protein | Antitoxin |
| P7I94_RS31555 (P7I94_31560) | 6591939..6593873 | - | 1935 | WP_010792482.1 | hypothetical protein | - |
| P7I94_RS31560 (P7I94_31570) | 6595182..6595706 | + | 525 | WP_010792479.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 6531223..6600477 | 69254 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19011.47 Da Isoelectric Point: 4.4540
>T280987 WP_021018402.1 NZ_CP124657:c6591337-6590813 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14810.93 Da Isoelectric Point: 7.2048
>AT280987 WP_010792483.1 NZ_CP124657:c6591729-6591334 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A212BIN6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I0C738 |