Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4921297..4922555 Replicon chromosome
Accession NZ_CP124657
Organism Pseudomonas aeruginosa strain 2022CK-00069

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I94_RS23765 Protein ID WP_003086331.1
Coordinates 4921297..4922052 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I94_RS23770 Protein ID WP_003086329.1
Coordinates 4922187..4922555 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I94_RS23755 (P7I94_23760) 4916468..4919011 + 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -
P7I94_RS23760 (P7I94_23765) 4919166..4920527 - 1362 WP_003081943.1 DNA recombination protein RmuC -
P7I94_RS23765 (P7I94_23770) 4921297..4922052 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I94_RS23770 (P7I94_23775) 4922187..4922555 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I94_RS23775 (P7I94_23780) 4922628..4923914 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I94_RS23780 (P7I94_23785) 4923970..4925463 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P7I94_RS23785 (P7I94_23790) 4925638..4926114 + 477 WP_004353334.1 elongation factor GreAB -
P7I94_RS23790 (P7I94_23795) 4926117..4926377 - 261 WP_023095977.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280985 WP_003086331.1 NZ_CP124657:c4922052-4921297 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280985 WP_003086329.1 NZ_CP124657:c4922555-4922187 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References