280984

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3930755..3931975 Replicon chromosome
Accession NZ_CP124657
Organism Pseudomonas aeruginosa strain 2022CK-00069

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I94_RS18885 Protein ID WP_003110488.1
Coordinates 3931397..3931975 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I94_RS18880 Protein ID WP_003088112.1
Coordinates 3930755..3931309 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I94_RS18855 (P7I94_18860) 3926323..3926874 + 552 WP_003132721.1 XRE family transcriptional regulator -
P7I94_RS18860 (P7I94_18865) 3926871..3927269 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I94_RS18865 (P7I94_18870) 3927282..3927605 - 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I94_RS18870 (P7I94_18875) 3927936..3928397 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
P7I94_RS18875 (P7I94_18880) 3928402..3930597 + 2196 WP_023095788.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I94_RS18880 (P7I94_18885) 3930755..3931309 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P7I94_RS18885 (P7I94_18890) 3931397..3931975 + 579 WP_003110488.1 HD domain-containing protein Toxin
P7I94_RS18890 (P7I94_18895) 3932085..3933272 - 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I94_RS18895 (P7I94_18900) 3933262..3935433 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
P7I94_RS18900 (P7I94_18905) 3935423..3936700 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T280984 WP_003110488.1 NZ_CP124657:3931397-3931975 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT280984 WP_003088112.1 NZ_CP124657:3930755-3931309 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References