Detailed information of TA system TA280982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 1647506..1649201
• Replicon: chromosome
• Accession: NZ_CP124657
• Organism: Pseudomonas aeruginosa strain 2022CK-00069

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: P7I94_RS07960
• Protein ID: WP_023095293.1
• Coordinates: 1647506..1648375 (+)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: Q9HYA1
• Locus tag: P7I94_RS07965
• Protein ID: WP_003112902.1
• Coordinates: 1648368..1649201 (+)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P7I94_RS07935 (P7I94_07935)	1643514..1644365	+	852	WP_003130104.1	ABC transporter ATP-binding protein	-
P7I94_RS07940 (P7I94_07940)	1644406..1645413	+	1008	WP_022579704.1	ABC transporter substrate-binding protein	-
P7I94_RS07945 (P7I94_07945)	1645410..1646186	+	777	WP_003112898.1	ABC transporter permease	-
P7I94_RS07950 (P7I94_07950)	1646192..1646953	+	762	WP_003112899.1	SDR family oxidoreductase	-
P7I94_RS07955 (P7I94_07955)	1646967..1647497	+	531	WP_003112900.1	cupin domain-containing protein	-
P7I94_RS07960 (P7I94_07960)	1647506..1648375	+	870	WP_023095293.1	alpha/beta hydrolase	Toxin
P7I94_RS07965 (P7I94_07965)	1648368..1649201	+	834	WP_003112902.1	IclR family transcriptional regulator	Antitoxin
P7I94_RS07970 (P7I94_07970)	1649188..1649985	+	798	WP_022579702.1	SDR family oxidoreductase	-
P7I94_RS07975 (P7I94_07975)	1649978..1651660	+	1683	WP_003112904.1	thiamine pyrophosphate-binding protein	-
P7I94_RS07980 (P7I94_07980)	1651671..1652474	+	804	WP_003112905.1	aspartate dehydrogenase	-
P7I94_RS07985 (P7I94_07985)	1652486..1653970	+	1485	WP_022579701.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (41-272)

Antitoxin

• Transcription regulator IclR, N-terminal (16-66)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30379.61 Da
• Isoelectric Point: 6.8139

>T280982 WP_023095293.1 NZ_CP124657:1647506-1648375 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPISGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Nucleotide

• Length: 870 bp

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30877.26 Da
• Isoelectric Point: 5.7725

>AT280982 WP_003112902.1 NZ_CP124657:1648368-1649201 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Nucleotide

• Length: 834 bp

Structures

Antitoxin

• AlphaFold DB: Q9HYA1