280981

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142969..143474 Replicon chromosome
Accession NZ_CP124657
Organism Pseudomonas aeruginosa strain 2022CK-00069

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag P7I94_RS01095 Protein ID WP_003083773.1
Coordinates 142969..143250 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag P7I94_RS01100 Protein ID WP_003083775.1
Coordinates 143247..143474 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I94_RS01070 (P7I94_01070) 138220..139569 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
P7I94_RS01075 (P7I94_01075) 139618..140304 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P7I94_RS01080 (P7I94_01080) 140405..141139 + 735 WP_003083764.1 GntR family transcriptional regulator -
P7I94_RS01085 (P7I94_01085) 141319..141729 + 411 WP_003110659.1 aegerolysin family protein -
P7I94_RS01090 (P7I94_01090) 141761..142669 - 909 Protein_131 LysR family transcriptional regulator -
P7I94_RS01095 (P7I94_01095) 142969..143250 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
P7I94_RS01100 (P7I94_01100) 143247..143474 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
P7I94_RS01105 (P7I94_01105) 143650..144270 - 621 WP_003101226.1 hypothetical protein -
P7I94_RS01110 (P7I94_01110) 144371..144871 + 501 WP_003083778.1 LEA type 2 family protein -
P7I94_RS01115 (P7I94_01115) 144944..145285 + 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
P7I94_RS01120 (P7I94_01120) 145369..146796 - 1428 WP_282414928.1 GABA permease -
P7I94_RS01125 (P7I94_01125) 146965..148458 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T280981 WP_003083773.1 NZ_CP124657:c143250-142969 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT280981 WP_003083775.1 NZ_CP124657:c143474-143247 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References