Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5282385..5284080 Replicon chromosome
Accession NZ_CP124655
Organism Pseudomonas aeruginosa strain 2022CK-00096

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag P7I95_RS25260 Protein ID WP_023095293.1
Coordinates 5283211..5284080 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag P7I95_RS25255 Protein ID WP_003112902.1
Coordinates 5282385..5283218 (-) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I95_RS25235 (P7I95_25235) 5277616..5279100 - 1485 WP_022579701.1 aldehyde dehydrogenase -
P7I95_RS25240 (P7I95_25240) 5279112..5279915 - 804 WP_003112905.1 aspartate dehydrogenase -
P7I95_RS25245 (P7I95_25245) 5279926..5281608 - 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
P7I95_RS25250 (P7I95_25250) 5281601..5282398 - 798 WP_022579702.1 SDR family oxidoreductase -
P7I95_RS25255 (P7I95_25255) 5282385..5283218 - 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
P7I95_RS25260 (P7I95_25260) 5283211..5284080 - 870 WP_023095293.1 alpha/beta hydrolase Toxin
P7I95_RS25265 (P7I95_25265) 5284089..5284619 - 531 WP_003112900.1 cupin domain-containing protein -
P7I95_RS25270 (P7I95_25270) 5284633..5285394 - 762 WP_003112899.1 SDR family oxidoreductase -
P7I95_RS25275 (P7I95_25275) 5285400..5286176 - 777 WP_003112898.1 ABC transporter permease -
P7I95_RS25280 (P7I95_25280) 5286173..5287180 - 1008 WP_022579704.1 ABC transporter substrate-binding protein -
P7I95_RS25285 (P7I95_25285) 5287221..5288072 - 852 WP_003130104.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30379.61 Da        Isoelectric Point: 6.8139

>T280979 WP_023095293.1 NZ_CP124655:c5284080-5283211 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPISGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT280979 WP_003112902.1 NZ_CP124655:c5283218-5282385 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References