Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 4359730..4360283 Replicon chromosome
Accession NZ_CP124655
Organism Pseudomonas aeruginosa strain 2022CK-00096

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag P7I95_RS20685 Protein ID WP_010953434.1
Coordinates 4359730..4360023 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A431XAN4
Locus tag P7I95_RS20690 Protein ID WP_003155922.1
Coordinates 4360011..4360283 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I95_RS20665 (P7I95_20665) 4355625..4355771 - 147 Protein_4080 DNA binding protein -
P7I95_RS20675 (P7I95_20675) 4357230..4357910 + 681 WP_282425990.1 hypothetical protein -
P7I95_RS20680 (P7I95_20680) 4358327..4359736 + 1410 WP_034065764.1 site-specific integrase -
P7I95_RS20685 (P7I95_20685) 4359730..4360023 - 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I95_RS20690 (P7I95_20690) 4360011..4360283 - 273 WP_003155922.1 CopG family ribbon-helix-helix protein Antitoxin
P7I95_RS20695 (P7I95_20695) 4360407..4360652 - 246 WP_034065762.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4348689..4397382 48693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T280977 WP_010953434.1 NZ_CP124655:c4360023-4359730 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10369.53 Da        Isoelectric Point: 6.0804

>AT280977 WP_003155922.1 NZ_CP124655:c4360283-4360011 [Pseudomonas aeruginosa]
MATSIKIDDELKGRIQHLAGLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB A0A431XAN4

References