Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3232036..3233256 Replicon chromosome
Accession NZ_CP124655
Organism Pseudomonas aeruginosa strain 2022CK-00096

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I95_RS15610 Protein ID WP_003110488.1
Coordinates 3232036..3232614 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I95_RS15615 Protein ID WP_003088112.1
Coordinates 3232702..3233256 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I95_RS15595 (P7I95_15595) 3227311..3228588 + 1278 WP_003088104.1 TolC family protein -
P7I95_RS15600 (P7I95_15600) 3228578..3230749 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
P7I95_RS15605 (P7I95_15605) 3230739..3231926 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I95_RS15610 (P7I95_15610) 3232036..3232614 - 579 WP_003110488.1 HD domain-containing protein Toxin
P7I95_RS15615 (P7I95_15615) 3232702..3233256 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P7I95_RS15620 (P7I95_15620) 3233414..3235609 - 2196 WP_023095788.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I95_RS15625 (P7I95_15625) 3235614..3236075 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
P7I95_RS15630 (P7I95_15630) 3236406..3236729 + 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I95_RS15635 (P7I95_15635) 3236742..3237140 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I95_RS15640 (P7I95_15640) 3237137..3237688 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T280976 WP_003110488.1 NZ_CP124655:c3232614-3232036 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT280976 WP_003088112.1 NZ_CP124655:c3233256-3232702 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References