Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2192131..2193389 Replicon chromosome
Accession NZ_CP124655
Organism Pseudomonas aeruginosa strain 2022CK-00096

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I95_RS10475 Protein ID WP_003086331.1
Coordinates 2192634..2193389 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I95_RS10470 Protein ID WP_003086329.1
Coordinates 2192131..2192499 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I95_RS10450 (P7I95_10450) 2188309..2188569 + 261 WP_023095977.1 zinc ribbon domain-containing protein -
P7I95_RS10455 (P7I95_10455) 2188572..2189048 - 477 WP_004353334.1 elongation factor GreAB -
P7I95_RS10460 (P7I95_10460) 2189223..2190716 + 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P7I95_RS10465 (P7I95_10465) 2190772..2192058 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I95_RS10470 (P7I95_10470) 2192131..2192499 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I95_RS10475 (P7I95_10475) 2192634..2193389 + 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I95_RS10480 (P7I95_10480) 2194159..2195520 + 1362 WP_003081943.1 DNA recombination protein RmuC -
P7I95_RS10485 (P7I95_10485) 2195675..2198218 - 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280975 WP_003086331.1 NZ_CP124655:2192634-2193389 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280975 WP_003086329.1 NZ_CP124655:2192131-2192499 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References