Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1423051..1423637 Replicon chromosome
Accession NZ_CP124655
Organism Pseudomonas aeruginosa strain 2022CK-00096

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I95_RS06695 Protein ID WP_003120987.1
Coordinates 1423051..1423350 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I95_RS06700 Protein ID WP_003448662.1
Coordinates 1423347..1423637 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I95_RS06675 (P7I95_06675) 1418167..1418700 - 534 WP_003120993.1 type IV pilus biogenesis protein PilP -
P7I95_RS06680 (P7I95_06680) 1418690..1420015 - 1326 WP_003120992.1 type 4b pilus protein PilO2 -
P7I95_RS06685 (P7I95_06685) 1420019..1421728 - 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
P7I95_RS06690 (P7I95_06690) 1421728..1422849 - 1122 WP_003448658.1 TcpQ domain-containing protein -
P7I95_RS06695 (P7I95_06695) 1423051..1423350 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I95_RS06700 (P7I95_06700) 1423347..1423637 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I95_RS06705 (P7I95_06705) 1423708..1424052 - 345 WP_003448665.1 hypothetical protein -
P7I95_RS06710 (P7I95_06710) 1424049..1424183 - 135 WP_033179080.1 hypothetical protein -
P7I95_RS06715 (P7I95_06715) 1424193..1426169 - 1977 WP_010792226.1 DEAD/DEAH box helicase -
P7I95_RS06720 (P7I95_06720) 1426166..1428055 - 1890 WP_003448700.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1370255..1451796 81541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T280974 WP_003120987.1 NZ_CP124655:1423051-1423350 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT280974 WP_003448662.1 NZ_CP124655:1423347-1423637 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References