Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4544380..4545638 Replicon chromosome
Accession NZ_CP124654
Organism Pseudomonas aeruginosa strain 2021CK-01851

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I92_RS21130 Protein ID WP_003086331.1
Coordinates 4544380..4545135 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I92_RS21135 Protein ID WP_003086329.1
Coordinates 4545270..4545638 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I92_RS21120 (P7I92_21120) 4539548..4542091 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
P7I92_RS21125 (P7I92_21125) 4542246..4543607 - 1362 WP_073647918.1 DNA recombination protein RmuC -
P7I92_RS21130 (P7I92_21130) 4544380..4545135 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I92_RS21135 (P7I92_21135) 4545270..4545638 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I92_RS21140 (P7I92_21140) 4545711..4546997 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I92_RS21145 (P7I92_21145) 4547053..4548546 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P7I92_RS21150 (P7I92_21150) 4548721..4549197 + 477 WP_004353334.1 elongation factor GreAB -
P7I92_RS21155 (P7I92_21155) 4549200..4549475 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280971 WP_003086331.1 NZ_CP124654:c4545135-4544380 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280971 WP_003086329.1 NZ_CP124654:c4545638-4545270 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References