Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3594467..3595687 | Replicon | chromosome |
| Accession | NZ_CP124654 | ||
| Organism | Pseudomonas aeruginosa strain 2021CK-01851 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | P7I92_RS16665 | Protein ID | WP_058156588.1 |
| Coordinates | 3595109..3595687 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | P7I92_RS16660 | Protein ID | WP_003088112.1 |
| Coordinates | 3594467..3595021 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P7I92_RS16635 (P7I92_16635) | 3590035..3590586 | + | 552 | WP_171892982.1 | helix-turn-helix transcriptional regulator | - |
| P7I92_RS16640 (P7I92_16640) | 3590583..3590981 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| P7I92_RS16645 (P7I92_16645) | 3590994..3591317 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| P7I92_RS16650 (P7I92_16650) | 3591648..3592109 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| P7I92_RS16655 (P7I92_16655) | 3592114..3594309 | + | 2196 | WP_171892983.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| P7I92_RS16660 (P7I92_16660) | 3594467..3595021 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| P7I92_RS16665 (P7I92_16665) | 3595109..3595687 | + | 579 | WP_058156588.1 | HD domain-containing protein | Toxin |
| P7I92_RS16670 (P7I92_16670) | 3595796..3596983 | - | 1188 | WP_021264658.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| P7I92_RS16675 (P7I92_16675) | 3596973..3599144 | - | 2172 | WP_282414986.1 | type I secretion system permease/ATPase | - |
| P7I92_RS16680 (P7I92_16680) | 3599134..3600411 | - | 1278 | WP_003139889.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21943.78 Da Isoelectric Point: 5.3655
>T280970 WP_058156588.1 NZ_CP124654:3595109-3595687 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQTAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQTAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT280970 WP_003088112.1 NZ_CP124654:3594467-3595021 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|