Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1807113..1808621 Replicon chromosome
Accession NZ_CP124654
Organism Pseudomonas aeruginosa strain 2021CK-01851

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag P7I92_RS08420 Protein ID WP_003119682.1
Coordinates 1807113..1807700 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag P7I92_RS08425 Protein ID WP_124090262.1
Coordinates 1807767..1808621 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I92_RS08415 (P7I92_08415) 1803368..1806847 - 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
P7I92_RS08420 (P7I92_08420) 1807113..1807700 + 588 WP_003119682.1 GNAT family protein Toxin
P7I92_RS08425 (P7I92_08425) 1807767..1808621 + 855 WP_124090262.1 AraC family transcriptional regulator Antitoxin
P7I92_RS08430 (P7I92_08430) 1808718..1810883 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
P7I92_RS08435 (P7I92_08435) 1811058..1812932 + 1875 WP_003091605.1 MFS transporter -
P7I92_RS08440 (P7I92_08440) 1812993..1813202 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T280969 WP_003119682.1 NZ_CP124654:1807113-1807700 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31822.10 Da        Isoelectric Point: 7.3038

>AT280969 WP_124090262.1 NZ_CP124654:1807767-1808621 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVYLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACAGSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References