Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6755517..6756022 Replicon chromosome
Accession NZ_CP124652
Organism Pseudomonas aeruginosa strain 2020CK-00443

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag P7I82_RS31875 Protein ID WP_003083773.1
Coordinates 6755741..6756022 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag P7I82_RS31870 Protein ID WP_003083775.1
Coordinates 6755517..6755744 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I82_RS31845 (P7I82_31845) 6750533..6752026 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
P7I82_RS31850 (P7I82_31850) 6752195..6753622 + 1428 WP_003083784.1 GABA permease -
P7I82_RS31855 (P7I82_31855) 6753706..6754047 - 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
P7I82_RS31860 (P7I82_31860) 6754120..6754620 - 501 WP_003083778.1 LEA type 2 family protein -
P7I82_RS31865 (P7I82_31865) 6754721..6755341 + 621 WP_003101226.1 hypothetical protein -
P7I82_RS31870 (P7I82_31870) 6755517..6755744 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
P7I82_RS31875 (P7I82_31875) 6755741..6756022 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
P7I82_RS31880 (P7I82_31880) 6756322..6757230 + 909 WP_003083769.1 LysR family transcriptional regulator -
P7I82_RS31885 (P7I82_31885) 6757262..6757672 - 411 WP_003110659.1 aegerolysin family protein -
P7I82_RS31890 (P7I82_31890) 6757852..6758586 - 735 WP_003083764.1 GntR family transcriptional regulator -
P7I82_RS31895 (P7I82_31895) 6758687..6759373 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P7I82_RS31900 (P7I82_31900) 6759422..6760771 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T280967 WP_003083773.1 NZ_CP124652:6755741-6756022 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT280967 WP_003083775.1 NZ_CP124652:6755517-6755744 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References