280966

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5203889..5205584 Replicon chromosome
Accession NZ_CP124652
Organism Pseudomonas aeruginosa strain 2020CK-00443

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag P7I82_RS24690 Protein ID WP_023095293.1
Coordinates 5204715..5205584 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag P7I82_RS24685 Protein ID WP_003112902.1
Coordinates 5203889..5204722 (-) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I82_RS24665 (P7I82_24665) 5199120..5200604 - 1485 WP_022579701.1 aldehyde dehydrogenase -
P7I82_RS24670 (P7I82_24670) 5200616..5201419 - 804 WP_003112905.1 aspartate dehydrogenase -
P7I82_RS24675 (P7I82_24675) 5201430..5203112 - 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
P7I82_RS24680 (P7I82_24680) 5203105..5203902 - 798 WP_022579702.1 SDR family oxidoreductase -
P7I82_RS24685 (P7I82_24685) 5203889..5204722 - 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
P7I82_RS24690 (P7I82_24690) 5204715..5205584 - 870 WP_023095293.1 alpha/beta hydrolase Toxin
P7I82_RS24695 (P7I82_24695) 5205593..5206123 - 531 WP_003112900.1 cupin domain-containing protein -
P7I82_RS24700 (P7I82_24700) 5206137..5206898 - 762 WP_003112899.1 SDR family oxidoreductase -
P7I82_RS24705 (P7I82_24705) 5206904..5207680 - 777 WP_003112898.1 ABC transporter permease -
P7I82_RS24710 (P7I82_24710) 5207677..5208684 - 1008 WP_022579704.1 ABC transporter substrate-binding protein -
P7I82_RS24715 (P7I82_24715) 5208725..5209576 - 852 WP_003130104.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30379.61 Da        Isoelectric Point: 6.8139

>T280966 WP_023095293.1 NZ_CP124652:c5205584-5204715 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPISGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT280966 WP_003112902.1 NZ_CP124652:c5204722-5203889 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References