280965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4932387..4933895 Replicon chromosome
Accession NZ_CP124652
Organism Pseudomonas aeruginosa strain 2020CK-00443

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag P7I82_RS23410 Protein ID WP_003119682.1
Coordinates 4933308..4933895 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9E8LAI1
Locus tag P7I82_RS23405 Protein ID WP_003117606.1
Coordinates 4932387..4933241 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I82_RS23390 (P7I82_23390) 4927806..4928015 + 210 WP_003091604.1 cold-shock protein -
P7I82_RS23395 (P7I82_23395) 4928076..4929950 - 1875 WP_003117607.1 MFS transporter -
P7I82_RS23400 (P7I82_23400) 4930125..4932290 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
P7I82_RS23405 (P7I82_23405) 4932387..4933241 - 855 WP_003117606.1 AraC family transcriptional regulator Antitoxin
P7I82_RS23410 (P7I82_23410) 4933308..4933895 - 588 WP_003119682.1 GNAT family protein Toxin
P7I82_RS23415 (P7I82_23415) 4934161..4937640 + 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T280965 WP_003119682.1 NZ_CP124652:c4933895-4933308 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31863.14 Da        Isoelectric Point: 7.5295

>AT280965 WP_003117606.1 NZ_CP124652:c4933241-4932387 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References