280964

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 4291591..4292144 Replicon chromosome
Accession NZ_CP124652
Organism Pseudomonas aeruginosa strain 2020CK-00443

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag P7I82_RS20170 Protein ID WP_010953434.1
Coordinates 4291591..4291884 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A431XAN4
Locus tag P7I82_RS20175 Protein ID WP_003155922.1
Coordinates 4291872..4292144 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I82_RS20150 (P7I82_20150) 4287486..4287632 - 147 Protein_3977 DNA binding protein -
P7I82_RS20160 (P7I82_20160) 4289091..4289771 + 681 WP_282425990.1 hypothetical protein -
P7I82_RS20165 (P7I82_20165) 4290188..4291597 + 1410 WP_034065764.1 site-specific integrase -
P7I82_RS20170 (P7I82_20170) 4291591..4291884 - 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I82_RS20175 (P7I82_20175) 4291872..4292144 - 273 WP_003155922.1 CopG family ribbon-helix-helix protein Antitoxin
P7I82_RS20180 (P7I82_20180) 4292268..4292513 - 246 WP_034065762.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4262880..4330163 67283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T280964 WP_010953434.1 NZ_CP124652:c4291884-4291591 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10369.53 Da        Isoelectric Point: 6.0804

>AT280964 WP_003155922.1 NZ_CP124652:c4292144-4291872 [Pseudomonas aeruginosa]
MATSIKIDDELKGRIQHLAGLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB A0A431XAN4

References