Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3169111..3170331 Replicon chromosome
Accession NZ_CP124652
Organism Pseudomonas aeruginosa strain 2020CK-00443

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I82_RS15145 Protein ID WP_003110488.1
Coordinates 3169111..3169689 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I82_RS15150 Protein ID WP_003088112.1
Coordinates 3169777..3170331 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I82_RS15130 (P7I82_15130) 3164386..3165663 + 1278 WP_003088104.1 TolC family protein -
P7I82_RS15135 (P7I82_15135) 3165653..3167824 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
P7I82_RS15140 (P7I82_15140) 3167814..3169001 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I82_RS15145 (P7I82_15145) 3169111..3169689 - 579 WP_003110488.1 HD domain-containing protein Toxin
P7I82_RS15150 (P7I82_15150) 3169777..3170331 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P7I82_RS15155 (P7I82_15155) 3170489..3172684 - 2196 WP_023095788.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I82_RS15160 (P7I82_15160) 3172689..3173150 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
P7I82_RS15165 (P7I82_15165) 3173481..3173804 + 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I82_RS15170 (P7I82_15170) 3173817..3174215 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I82_RS15175 (P7I82_15175) 3174212..3174763 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T280963 WP_003110488.1 NZ_CP124652:c3169689-3169111 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT280963 WP_003088112.1 NZ_CP124652:c3170331-3169777 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References