Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2128129..2129387 Replicon chromosome
Accession NZ_CP124652
Organism Pseudomonas aeruginosa strain 2020CK-00443

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I82_RS10000 Protein ID WP_003086331.1
Coordinates 2128632..2129387 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I82_RS09995 Protein ID WP_003086329.1
Coordinates 2128129..2128497 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I82_RS09975 (P7I82_09975) 2124307..2124567 + 261 WP_023095977.1 zinc ribbon domain-containing protein -
P7I82_RS09980 (P7I82_09980) 2124570..2125046 - 477 WP_004353334.1 elongation factor GreAB -
P7I82_RS09985 (P7I82_09985) 2125221..2126714 + 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P7I82_RS09990 (P7I82_09990) 2126770..2128056 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I82_RS09995 (P7I82_09995) 2128129..2128497 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I82_RS10000 (P7I82_10000) 2128632..2129387 + 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I82_RS10005 (P7I82_10005) 2130157..2131518 + 1362 WP_003081943.1 DNA recombination protein RmuC -
P7I82_RS10010 (P7I82_10010) 2131673..2134216 - 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280962 WP_003086331.1 NZ_CP124652:2128632-2129387 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280962 WP_003086329.1 NZ_CP124652:2128129-2128497 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References