280961

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1401787..1402373 Replicon chromosome
Accession NZ_CP124652
Organism Pseudomonas aeruginosa strain 2020CK-00443

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I82_RS06545 Protein ID WP_003120987.1
Coordinates 1401787..1402086 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I82_RS06550 Protein ID WP_003448662.1
Coordinates 1402083..1402373 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I82_RS06525 (P7I82_06525) 1396903..1397436 - 534 WP_003120993.1 type IV pilus biogenesis protein PilP -
P7I82_RS06530 (P7I82_06530) 1397426..1398751 - 1326 WP_003120992.1 type 4b pilus protein PilO2 -
P7I82_RS06535 (P7I82_06535) 1398755..1400464 - 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
P7I82_RS06540 (P7I82_06540) 1400464..1401585 - 1122 WP_003448658.1 TcpQ domain-containing protein -
P7I82_RS06545 (P7I82_06545) 1401787..1402086 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I82_RS06550 (P7I82_06550) 1402083..1402373 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I82_RS06555 (P7I82_06555) 1402444..1402788 - 345 WP_003448665.1 hypothetical protein -
P7I82_RS06560 (P7I82_06560) 1402785..1402919 - 135 WP_033179080.1 hypothetical protein -
P7I82_RS06565 (P7I82_06565) 1402929..1404905 - 1977 WP_010792226.1 DEAD/DEAH box helicase -
P7I82_RS06570 (P7I82_06570) 1404902..1406791 - 1890 WP_003448700.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1348991..1430532 81541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T280961 WP_003120987.1 NZ_CP124652:1401787-1402086 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT280961 WP_003448662.1 NZ_CP124652:1402083-1402373 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References