Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5720061..5720647 Replicon chromosome
Accession NZ_CP124651
Organism Pseudomonas aeruginosa strain 2020CK-00217

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I79_RS26915 Protein ID WP_003120987.1
Coordinates 5720348..5720647 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I79_RS26910 Protein ID WP_003448662.1
Coordinates 5720061..5720351 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I79_RS26890 (P7I79_26890) 5715643..5717532 + 1890 WP_003448700.1 hypothetical protein -
P7I79_RS26895 (P7I79_26895) 5717529..5719505 + 1977 WP_010792226.1 DEAD/DEAH box helicase -
P7I79_RS26900 (P7I79_26900) 5719515..5719649 + 135 WP_033179080.1 hypothetical protein -
P7I79_RS26905 (P7I79_26905) 5719646..5719990 + 345 WP_003448665.1 hypothetical protein -
P7I79_RS26910 (P7I79_26910) 5720061..5720351 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I79_RS26915 (P7I79_26915) 5720348..5720647 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I79_RS26920 (P7I79_26920) 5720849..5721970 + 1122 WP_003448658.1 TcpQ domain-containing protein -
P7I79_RS26925 (P7I79_26925) 5721970..5723679 + 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
P7I79_RS26930 (P7I79_26930) 5723683..5725008 + 1326 WP_003120992.1 type 4b pilus protein PilO2 -
P7I79_RS26935 (P7I79_26935) 5724998..5725531 + 534 WP_003120993.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5694849..5748063 53214


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T280957 WP_003120987.1 NZ_CP124651:c5720647-5720348 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT280957 WP_003448662.1 NZ_CP124651:c5720351-5720061 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References