Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2620325..2620878 Replicon chromosome
Accession NZ_CP124651
Organism Pseudomonas aeruginosa strain 2020CK-00217

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag P7I79_RS12355 Protein ID WP_010953434.1
Coordinates 2620585..2620878 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A431XAN4
Locus tag P7I79_RS12350 Protein ID WP_003155922.1
Coordinates 2620325..2620597 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I79_RS12345 (P7I79_12345) 2619956..2620201 + 246 WP_034065762.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
P7I79_RS12350 (P7I79_12350) 2620325..2620597 + 273 WP_003155922.1 CopG family ribbon-helix-helix protein Antitoxin
P7I79_RS12355 (P7I79_12355) 2620585..2620878 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I79_RS12360 (P7I79_12360) 2620872..2622281 - 1410 WP_034065764.1 site-specific integrase -
P7I79_RS12365 (P7I79_12365) 2622698..2623399 - 702 WP_031640384.1 hypothetical protein -
P7I79_RS12370 (P7I79_12370) 2623515..2623661 + 147 Protein_2443 DNA binding protein -
P7I79_RS12375 (P7I79_12375) 2623789..2625579 - 1791 WP_023095445.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2585999..2629704 43705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T280954 WP_010953434.1 NZ_CP124651:2620585-2620878 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10369.53 Da        Isoelectric Point: 6.0804

>AT280954 WP_003155922.1 NZ_CP124651:2620325-2620597 [Pseudomonas aeruginosa]
MATSIKIDDELKGRIQHLAGLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB A0A431XAN4

References