280952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1709836..1711531 Replicon chromosome
Accession NZ_CP124651
Organism Pseudomonas aeruginosa strain 2020CK-00217

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag P7I79_RS07855 Protein ID WP_023095293.1
Coordinates 1709836..1710705 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag P7I79_RS07860 Protein ID WP_003112902.1
Coordinates 1710698..1711531 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I79_RS07830 (P7I79_07830) 1705844..1706695 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
P7I79_RS07835 (P7I79_07835) 1706736..1707743 + 1008 WP_022579704.1 ABC transporter substrate-binding protein -
P7I79_RS07840 (P7I79_07840) 1707740..1708516 + 777 WP_003112898.1 ABC transporter permease -
P7I79_RS07845 (P7I79_07845) 1708522..1709283 + 762 WP_003112899.1 SDR family oxidoreductase -
P7I79_RS07850 (P7I79_07850) 1709297..1709827 + 531 WP_003112900.1 cupin domain-containing protein -
P7I79_RS07855 (P7I79_07855) 1709836..1710705 + 870 WP_023095293.1 alpha/beta hydrolase Toxin
P7I79_RS07860 (P7I79_07860) 1710698..1711531 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
P7I79_RS07865 (P7I79_07865) 1711518..1712315 + 798 WP_022579702.1 SDR family oxidoreductase -
P7I79_RS07870 (P7I79_07870) 1712308..1713990 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
P7I79_RS07875 (P7I79_07875) 1714001..1714804 + 804 WP_003112905.1 aspartate dehydrogenase -
P7I79_RS07880 (P7I79_07880) 1714816..1716300 + 1485 WP_022579701.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30379.61 Da        Isoelectric Point: 6.8139

>T280952 WP_023095293.1 NZ_CP124651:1709836-1710705 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPISGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT280952 WP_003112902.1 NZ_CP124651:1710698-1711531 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References