280951

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 199728..200233 Replicon chromosome
Accession NZ_CP124651
Organism Pseudomonas aeruginosa strain 2020CK-00217

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag P7I79_RS00965 Protein ID WP_003083773.1
Coordinates 199728..200009 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag P7I79_RS00970 Protein ID WP_003083775.1
Coordinates 200006..200233 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I79_RS00940 (P7I79_00940) 194979..196328 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
P7I79_RS00945 (P7I79_00945) 196377..197063 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P7I79_RS00950 (P7I79_00950) 197164..197898 + 735 WP_003083764.1 GntR family transcriptional regulator -
P7I79_RS00955 (P7I79_00955) 198078..198488 + 411 WP_003110659.1 aegerolysin family protein -
P7I79_RS00960 (P7I79_00960) 198520..199428 - 909 WP_003083769.1 LysR family transcriptional regulator -
P7I79_RS00965 (P7I79_00965) 199728..200009 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
P7I79_RS00970 (P7I79_00970) 200006..200233 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
P7I79_RS00975 (P7I79_00975) 200409..201029 - 621 WP_003101226.1 hypothetical protein -
P7I79_RS00980 (P7I79_00980) 201130..201630 + 501 WP_003083778.1 LEA type 2 family protein -
P7I79_RS00985 (P7I79_00985) 201703..202044 + 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
P7I79_RS00990 (P7I79_00990) 202128..203555 - 1428 WP_003083784.1 GABA permease -
P7I79_RS00995 (P7I79_00995) 203724..205217 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T280951 WP_003083773.1 NZ_CP124651:c200009-199728 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT280951 WP_003083775.1 NZ_CP124651:c200233-200006 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References