Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5029676..5030934 Replicon chromosome
Accession NZ_CP124649
Organism Pseudomonas aeruginosa strain 2020CK-00218

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I80_RS23765 Protein ID WP_003086331.1
Coordinates 5029676..5030431 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I80_RS23770 Protein ID WP_003086329.1
Coordinates 5030566..5030934 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I80_RS23755 (P7I80_23755) 5024847..5027390 + 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -
P7I80_RS23760 (P7I80_23760) 5027545..5028906 - 1362 WP_003081943.1 DNA recombination protein RmuC -
P7I80_RS23765 (P7I80_23765) 5029676..5030431 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I80_RS23770 (P7I80_23770) 5030566..5030934 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I80_RS23775 (P7I80_23775) 5031007..5032293 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I80_RS23780 (P7I80_23780) 5032349..5033842 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P7I80_RS23785 (P7I80_23785) 5034017..5034493 + 477 WP_004353334.1 elongation factor GreAB -
P7I80_RS23790 (P7I80_23790) 5034496..5034756 - 261 WP_023095977.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280948 WP_003086331.1 NZ_CP124649:c5030431-5029676 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280948 WP_003086329.1 NZ_CP124649:c5030934-5030566 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References