Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3979018..3980238 Replicon chromosome
Accession NZ_CP124649
Organism Pseudomonas aeruginosa strain 2020CK-00218

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I80_RS18585 Protein ID WP_003110488.1
Coordinates 3979660..3980238 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I80_RS18580 Protein ID WP_003088112.1
Coordinates 3979018..3979572 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I80_RS18555 (P7I80_18555) 3974586..3975137 + 552 WP_003132721.1 XRE family transcriptional regulator -
P7I80_RS18560 (P7I80_18560) 3975134..3975532 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I80_RS18565 (P7I80_18565) 3975545..3975868 - 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I80_RS18570 (P7I80_18570) 3976199..3976660 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
P7I80_RS18575 (P7I80_18575) 3976665..3978860 + 2196 WP_023095788.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I80_RS18580 (P7I80_18580) 3979018..3979572 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P7I80_RS18585 (P7I80_18585) 3979660..3980238 + 579 WP_003110488.1 HD domain-containing protein Toxin
P7I80_RS18590 (P7I80_18590) 3980348..3981535 - 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I80_RS18595 (P7I80_18595) 3981525..3983696 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
P7I80_RS18600 (P7I80_18600) 3983686..3984963 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T280947 WP_003110488.1 NZ_CP124649:3979660-3980238 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT280947 WP_003088112.1 NZ_CP124649:3979018-3979572 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References